old friends hypothesis造句

The " old friends hypothesis " proposed in 2003 may offer a better explanation for the link between microbial exposure and inflammatory diseases.
In 2003 Graham Rook proposed the " old friends hypothesis " which seems to offer a more rational explanation for the link between microbial exposure and inflammatory disorders.
The old friends hypothesis modifies the hygiene hypothesis by proposing that regulatory T cells can only become fully effective if they are stimulated by exposure to microorganisms and parasites that have low levels of pathogenicity and that have coexisted universally with human beings throughout our evolutionary history.
In support of the old friends hypothesis, the intestinal microbiome was found to differ between allergic and non-allergic Estonian and Swedish children but this finding was not replicated in a larger cohort and the biodiversity of the intestinal flora in patients with Crohn s disease was diminished.
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